Link: https://link.springer.com/article/10.1007/s42399-020-00562-z

Autores: SILVA, L B ; KLAFKE, G. B. ; POESTER, V. R. ; SANCHOTENE, K. O. ; RAMIS, I. B. ; SILVA, P. E. A. ; BASSO, R. ; SILVEIRA, J. M. ; XAVIER, M. O. .  

Periódico: SN Comprehensive Clinical Medicine

Resumo: Cryptococcosis (Cr) and tuberculosis (TB) are infectious diseases potentially fatal to HIV-AIDS patients, and coinfection with Cr/TB in endemic regions may represent a new challenge in the panorama of the HIV-AIDS pandemic. This retrospective study aims to describe the clinic-epidemiological data of cryptococcosis and tuberculosis (Cr/TB) coinfection in HIV-AIDS patients from Southern Brazil. A retrospective study including all cases of coinfection by the Cryptococcus neoformans species complex and Mycobacterium tuberculosis, diagnosed in HIV-AIDS patients at the Specialized Customer Service of University Hospital – Federal University of Rio Grande (SAE-HU-FURG), during the period January 2010 to December 2012 was performed. During the 3 years of study, ten cases of Cr/TB coinfection were detected. The mean age was 39.3 years and 80% were male. Cr meningitis with pulmonary TB occurred in 40% of the cases and pulmonary presentation in both diseases occurred in 30%. The mean TCD4 + rate was 118.6 cel/mm³ (SD = 135.36), with 80% of the patients maintaining TCD4 + < 100 cells/mm³. The viral load presented by 70% of the patients was equal or higher than 100,000 copies/mm³. Four patients (40%) died on an average, 29 days (SD = 8.75) after diagnosis of the coinfection. The study shows the necessity of a broad diagnostic investigation in the context of Cr/TB/HIV-AIDS coinfection.