Link: https://www.scielo.br/j/abmvz/a/FLtZYR3zZbXGj4B6kxYX3yR/?lang=pt

Autores: CLEFF, M. B. ; MEINERZ, A. R. M. ; FARIA, R. O. ; XAVIER, M. O. ; SANTIN, R. ; NASCENTE, P. S. ; Rodrigues, M.R.A. ; MEIRELES, M. C. A. .

Periódico:  Arquivo Brasileiro de Medicina Veterinária e Zootecnia

Resumo: The in vitro activity of Origanum vulgare essential oil against fungal isolates was evaluated. A total of 27 clinical isolates were used, including: C. albicans, S. schenckii, M. pachydermatis, Aspergillus flavus, and A. fumigatus. Microdilution in broth technique (NCCLS M27-A2 and M-38) was used and susceptibility was expressed as Minimum Inhibitory Concentration (MIC). Essential oil was obtained by hydrodistillation in Clevenger and analyzed by gas chromatography, showing the presence of 4-terpineol, alpha-terpineol, 4-terpinene, thymol and carvacrol, as the main compounds. Origanum oil MIC for C. albicans varied from 125 to 500mL/mL; for S. schenckii, from 250 to 500mL/mL; for M. pachydermatis, from 15 to 30mL/mL; and for Aspergillus, from 30 to 60mL/mL. Isolates sensitivity showed to the origanum oil stimulates the accomplishment of new studies, including in vivo tests, contributing to the search of alternative treatments to mycosis.

Palavras-chave: fungal, essential oil, origanum