Link: https://wwwnc.cdc.gov/eid/article/28/3/21-2150_article
Autores: BASSO, R. P. ; POESTER, V. R. ; BENELLI, J. L. ; STEVENS, DAVID A ; XAVIER, M. O. .
Periódico: EMERGING INFECTIOUS DISEASES (ONLINE)
Resumo:
We evaluated disseminated histoplasmosis (DH) in HIV patients over 10 years in southern Brazil. The incidence was 12 cases/1,000 hospitalizations (2010–2019); the mortality rate was 35%. Tuberculosis frequently obscured the diagnosis of DH. We emphasize the need in our region to suspect and investigate DH using more sensitive methods.
Disseminated histoplasmosis (DH) is an AIDS-defining disease and one of the major causes of death in persons living with HIV/AIDS (PLHIV) (mortality rate ranging from 13% to 48%) (1–4). DH is a neglected disease because of its nonspecific symptoms, frequent misdiagnosis as tuberculosis (TB), and limited access to sensitive diagnostic methods (3,5).
Worsening this scenario, an epidemic of AIDS is underway in Brazil; >800,000 new cases have been diagnosed in recent decades (6). Therefore, efforts are necessary to understand the epidemiology of DH/AIDS co-infection in the areas to which these diseases are endemic. We evaluated the clinical and epidemiologic profile of patients with DH/AIDS co-infection in a reference service for PLHIV over 10 years in southern Brazil and compared the incidence in periods before and after an internal hospital improvement of DH investigation.
