Link: https://www.scielo.br/j/abmvz/a/ygW3wdKMNC8tDBfCFPwpx6B/?lang=pt

Autores: Meinerz, A.R.M. ; Antunes, T.A. ; Silva, F.V. ; Xavier, M.O. ; Cleff, M.B. ; Meireles, M.C.A. ; Xavier, Melissa Orzechowski . 

Periódico:  Arquivo Brasileiro de Medicina Veterinária e Zootecnia

Resumo: Alanine aminotransferase (ALT) and alkaline phosphatase (AP) hepatic enzymes, hematological values, and total plasmatic proteins (TPP) of 12 Wistar rats with systemic experimental sporotrichosis were evaluated. Inoculation was performed at 2×10³ cells of S. schenckii/ml. The values ranged from 35 to 48UI/l for ALT and 67 to 251.3UI/l for AP. Fifty percent of the AP values were above the physiological limits. TPP was elevated in 66.7% (8/12) of the rats with values varying from 7.9 to 8.5g%. In 75% (9/12) of the animals, it was observed that hemoglobin and red blood cells count were below the physiologic limits, and 8.3% (1/12) of the animals showed anemia masked by dehydration. At the necropsy, it was observed local and/or disseminated nodular lesions. At the histological analysis, cells compatible to S. schenckii were found. The observed alterations are aggravating factors for the recurrence and treatment of the mycosis.

Palavras-chave: rat; experimental sporotrichosis; Sporothrix schenckii; hepatic enzymes