Link: https://link.springer.com/article/10.1007/s00284-021-02581-y
Autores: POESTER, VANICE RODRIGUES; MUNHOZ, LÍVIA SILVEIRA ; BENELLI, JÉSSICA LOUISE ; KLAFKE, GABRIEL BARACY ; NOGUEIRA, CRISTINA WAYNE ; ZENI, GILSON ROGÉRIO ; STEVENS, DAVID A. ; LARWOOD, DAVID ; XAVIER, MELISSA ORZECHOWSKI .
Periódico: CURRENT MICROBIOLOGY
Resumo: We evaluated the in vitro activity of nikkomycin Z (NikZ) in combination with diphenyl diselenide (PhSe)2, two compounds previously shown to have anti-Sporothrix spp. activity. Eighteen isolates of Sporothrix spp. were tested in checkerboard assays. Synergism for inhibition and killing Sporothrix spp. occurred in 100% and 89% of the isolates, respectively. The anti-Sporothrix spp. activity of this combination provides a rationale for in vivo studies to evaluate the application of both compounds in sporotrichosis treatment.
